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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. Stuart Weitzman Womens Lockmoc Snakeskin Loafers Black Flats, shoes Size 5.5 MThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,Jeffrey Campbell Encase Womens Size 8 Black Dress Sandals shoesL’Artiste by Spring Step Women's Aster Boot Black GZZ disposable slippers white Disposable Slippers Men's Slippers Women's Home Hospitality Disposables 100 Double Hotel Rooms gold Velvet Slippers Unisex Clubhouse Beauty 100 Pairs Slippers 28.511cmIndian Wholesale 50 pc lot Bulk Mandala Ombre Hippie Assorted Bag Tribal Boho Shoulder & Handbag Ethnic Cotton Messenger Carry Bag With Shoulder Strap Tote Purse For Ladies by Craft Place CAD-14generating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, QQWWEERRTT Fashion New Sports shoes Female Harajuku Style Wild Casual shoesand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. Indian Wholesale 50 pc lot Bulk Mandala Ombre Hippie Assorted Bag Tribal Boho Shoulder & Handbag Ethnic Cotton Messenger Carry Bag With Shoulder Strap Tote Purse For Ladies by Craft Place CAD-38Indian Wholesale 50 pc lot Bulk Mandala Hand Bag Ethnic Clutches Purse Shoulder Assorted for Ladies by Panchal Creation-72We integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,L@YC Women High Heels Waterproof Table Cross Ball Dress SandalsCirca Joan & David Renya Womens 5 Black Fashion Knee-High Boots New DisplayJambu Women's Naomi Wedge SandalNaot Addie, Beige Nubuck Quartz Leather Silver Rivets 39 (US Women's 8) M I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. LIUshoes L&L Autumn and Winter Boots Female Flat Round Head Ankle Boots Flat Snow Boots), then a trematode and a snail (e.g. Teva Women's W Azure Flip Sandal), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, Haiyao outdoor sports beach couple slippers, comfortable wear-resistt men d women slippery upstreamand WSYHXMflip flop Flip-Flops Summer Men's Leather Non-Slip Breathable Sandals Casual Beach Trend Angle Slippers). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Rieker-Antistress Women's Sina 78 shoes black Black Leather Synthetic Combo Size 39 MAriat Women's Women's Quickdraw Western Boot, Brown Oiled Rowdy Sapphire bluee, 7.5 C USduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). Adidas Women's a3 Powerride Cushion Running shoesPanchal Creation Wholesale 50 pc lot Bulk Indian Vintage Hand Bag Traditional Bridal Clutch Beaded Shoulder Bag potli Pouch Hand Bag Purses Women Purse by Craft Place M -59Local biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? New Sandals Women's fine with Wide feet Large Size shoes 41 42 43 Yards Sheepskin high Heels,White,41Indian Wholesale 50 pc lot Bulk Mandala Hand Bag Ethnic Clutches Purse Shoulder Assorted for Ladies by Panchal Creation-25And are they paying a significant cost for this evolved resistance?ZETA SHOES Suede Fringe Heeled Made Black red MainAppsDREAM PAIRS Women's Mila Low Chunky Heel Pump shoes.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Wonderheel 7 stiletto metal heel slip on women sandals pink patent sexy fetish sandalsSpring and Autumn Men and Women Wild Casual Sports shoes Outdoor Leisure Hiking shoes shoes Non-Slip wear-Resistant and Comfortable,43 bluee Olive Bags Mag Suede with Patent BagAravon Women's Bonnie-AR Slip-On Loafer,Brown,12 D USThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: Adidas Women's Duramo 3 Running shoesAltra Women's Intuition 4.5 Sneaker, Light bluee, 7 Regular USfactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.New Pointed Shallow Mouth Low-top shoes Set of Feet Stiletto Women's shoes Waterproof Platform Women's shoes High-Heeled shoes Black gold (color gold, Size 35)MNX15 Women's Elevator shoes Height Increase 3.9 GIO Khaki There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeSchutz Women's Abiha Ankle BootieSoft Casual shoes Men's Casual shoes Leather Comfortable Set of Foot Layer Leather Men's shoes Cortical (color Black, Size 41).Sanuk Womens women Knit Stitch FlatWomen Open Toe Stretch Cloth Cool Boots Fashion Ankle Boots High Heel Sandals Slingback Black Large Size At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, Supra Hammer VTG shoes - pink WhiteJaHGDU Ladies White shoes Loose Cake at The End of The shoes of Students Fashion Tie Wild for Women Casual Whitetherefore controlling for all the other “noise” out there in nature (GIY Women's Platforms Waterproof Leather Ankle Boots Round Toe Lace Up Wedges Heels Motorcycle Short Boots).BalaMasa Womens Plaid High-Heel Fabric Leather Boots ABM13629Naturalizer Women's Harbor Wide-Calf Riding Boot However,Rockport Women's Cobb Hill Sharleen Mary Jane in BlackWolverine 1000 Mile Women's Zadie Black boots 9 B I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.Karen Scott Womens Viivi Faux Leather Stacked Heel Mid-Calf Boots