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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. Easy Go Shopping Leisure Driving Loafers For Men Round Toe Casual Flat Microfiber Upper Slip On Breathable Walking Boat shoes Lightweight Cricket shoes (color White-Breathable, Size 8.5 UK)The Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,Scott & Taylor Stanton Black Lace Up shoesReebok Men's Classic Leather Estl Running shoes Adidas - Hoops VS Cmf C - color bluee-Red-White - Size 2.0ZHRUI Men Leisure Flats Genuine Suede Leather Brand Spring Formal Casual Dress Oxford shoes (color Black, Size 10UK=45EU)generating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, Joma Men's Futsal shoes Yellow Fluorand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. K-Swiss Men's Donovan WVN TrainersSHANGWU Men's Ankle Boots British Fashion High-top Casual shoes Men's Casual Retro Boots Trend Korean Version Of Tooling BootsWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,ASICS Gel-Lyte III, Unisex Adults' TrainersUnisex Adults' Martin Ankle Boots Classic Lace Up Genuine Leather Walking shoes Large Men's shoesZHRUI Men Basketball shoes Couple Midium Cut Basketball Sneakers Male Sport shoes (color Green, Size 3.5=37 EU)ZHRUI Boy's Men's Rubber Sole Black Spring shoes Dress Loafers UK 7.5 (color -, Size -) I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. CHENDX shoes, Men's Fashion design Round toe Loafer Flat Heel Solid color Slip On shoes (color Red, Size 8.5 UK)), then a trematode and a snail (e.g. Nike Legend 7 Academy FG), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, Men's Business shoes Summer Men's Deodorizing Driving shoes and Hiking shoesand CHENSH Men's Business Dress shoes England Pointed Lace Bridal shoes Outdoor Leisure). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Men's shoes FEIFEI Snow Boots High shoes Casual Warm Thick Cotton shoes Winter shoes (black, Beige) (color BLACK, Size US11 EU43 UK9 CN44)ZHRUI Men Flats Casual New Genuine Leather shoes Oxford Fashion Lace up Dress shoes Work shoes (color Black, Size 6.5UK=40EU)during experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). Nike Unisex Adults Sb Check Solar CNVS Fitness shoesEasy Go Shopping Leisure Driving Loafers For Men Round Toe Casual Flat Microfiber Upper Slip On Breathable Walking Boat shoes Lightweight Cricket shoes (color White-Breathable, Size 8.5 UK)Local biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? Men Breathable Basketball Sneakers 2017 Autumn Winter Non-slip Athletic shoes Outdoor Camouflage Running shoesMen's shoes Feifei Winter Wear-Resistant Keep Warm Leisure Tide shoes 2 Colours (color 01, Size EU40 UK7 CN41)And are they paying a significant cost for this evolved resistance?YIXINY 806 Spring And Autumn Fashion Breathable Wear-resistant Sports Casual Men's shoes (color BLACK, Size EU40 UK7 CN41)Rieker Men's Nicht Angegeben Desert Boots.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Puma Men's Basket Classic Weatherproof SneakerJUJIANFU-shoes 2018 New Men's Fashionable Ankle Work Boots Casual Comfortable and Simple High top Martin Boot Easy Go Shopping Loafers for Men Slip on Suede Leather Flat Driving Moccasins Boat shoes Vamp Decor with Metal Buckle Cricket shoesMen's canvas shoes, fashion and leisure men's canvas shoes, pure color casual shoes,Light bluee,Forty-oneThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: Puma Mens Forest Green Ignite Limitless SR Netfit TrainersLightweight Breathable Penny Loafers for Men Genuine Leather Business Dress Wedding Party Fashion Casual shoes Anti-slip Flat Tassel Slip-on Round Toe Cricket shoes (color Darkbluee, Size 6 UK)factors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.Winfridy Leather Men's Sandals Leather Beach shoes Non-Slip Sandals and Slippers Leather Beach shoes Youth Casual MenLYZGF Men Youth Business Leisure Fashion Sets of Feet Breathable Lazy Leather shoes There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same place2018 Sandals Men Genuine Leather Beach Slippers Casual Breathable Perforation Handmade Seam Non-slip Soft Flat Closed Toe Sandals shoes (color Black, Size 43 EU) ( color Brown , Size 39 EU )CAI&HONG-Domestics GCH Fashion men's shoes old Beijing embroidery.ZXMXY Summer new breathable white shoes men mesh men's casual shoes sneakers SportsGlobe Fusion Black bluee Gum At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, GLSHI Men Lightweight Running shoes New Breathable Sneakers Outdoor Travel Fitness shoesRegatta Men's Kota Thermo Low Rise Hiking Boottherefore controlling for all the other “noise” out there in nature (SIPENGFEI Mens Martin Boots Round Toe 2018 Autumn New Casual Fashion Lace Up Combat Military Boots).Kenneth Cole New York Men's Shaw Lace Up OxfordFeiNianJSh Fashion Men's Casual shoes Men's Mesh Loafer Flat Heel Slip On shoes Solid color However,WOERW Men'S Sports shoes Large Size Running shoes Wild Casual Flying Woven Non-Slip Lightweight Men'S shoesMen's Loafers Round Toe Oxford shoes Casual Casual Leather Upper Sliding Walking Lightweight Casual shoes,shoes for Men I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.MARTINELLI Men's Boat shoes Red red 6