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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. FEMAROLY Women's Sandals 2018 Roman Fish Mouth Buckle Solid colorThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,Karen Scott Womens Vanni Closed Toe Ankle Fashion BootsYooPrettyz Cutout Sandals Open Toe Rhinestone Wedding Dress Ankle Strap Flat Sandals ZENS Knitted Cotton Linen Home Slippers, Ultra Lightweight Indoor Flat Closed Toe with Anti-Slip Suede Sole, Soft Cozy & WashableThe small cat Women's shoes Sandals with Buckle High Heels gold and Silver Wedding shoesgenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, Women's Sandals, Fashion Summer Style Elastic T-Strap Bohemia Beaded Solid color shoesand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. Natural Soul Womens Jordana Flat SandalPhil Betty Women Flats shoes Cute Round Toe Cat Dog Comfort Fashion Casual Flats shoesWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,T-JULY Women Flat Flip Flops Sandals Light Casual Flat Slippers Fashion Women Outdoor Slippers Summer Beach SlippersJeff Tribble Fashion Women Knee High Boots Elastic Slim Autumn Winter Warm Long Thigh High shoes Size 40Tirahse Comfortable Women's Pu Solid Pull On Pointed Closed Toe Kitten Heels Pumps-shoesMeimeioo Women’s Round Toe Lace-up Ankle Boots Ladies Combat Booties Fashion Martens Boots I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. Gjsonmv Christmas Element Pattern mesh Lightweight shoes for Women Comfortable Sports Tennis Sneakers shoes), then a trematode and a snail (e.g. Kaloosh Women's Over The Knee Boots High Stretch Faux Sexy Pull Up Dress shoes High Heels), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, Classic colorful Print Women Casual Tennis shoes Platform Sneakers US 6and Summer Sexy gold Women 11Cm High Heels Silver Cross Strap Stripper Sandals Female Fetish shoes Lady Glossy Bling Pumps). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, DecoStain Women's Bowtie Slip On Mixed color Wedge Platform PumpsRismart Women's Mid-Calf Fur Lined Winter Leather Snow Bootsduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). Women shoes Beach Men Swimming Water shoes Pool Sports Surfing DivingKarl Conner Women Sandals with Pearls Summer shoes Fashion Thick High Heels SandalsLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? Women and Man Beach shoes Plus Size Outdoor Water shoes Couples Slip-on Aqua shoes Comfortable Wading SneakersMumeson Women Lightweight Running shoes Skull Clip Art Print Fashion SneakersAnd are they paying a significant cost for this evolved resistance?IWlxz Women's PU(Polyurethane) Summer Sandals Flat Heel White Black BeigeZipper Flat shoes Woman High Heel Platform PU Leather Boots Lace Up Cow Muscle shoes Martin Boots.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Chaqlin Super Lightweight Women's Outdoor shoes bluee pink Printed Lacing Canvas Sneakers Size 37FLourishing Mules for Women, Women Embroidery Linen Mule Slippers, Woman Slip on Backless Loafers Mumeson Classic Animal Print Women High Tops Fashion Sneakers Flats Platform shoesCOSDN Women's Men's Fashion Air Cushion Running Flyknit Sneakers Lightweight Sports Gym Jogging shoes(US 4.5～12.5)The costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: MsMushroom Woman's Classic Plaid Pu Latin Dance shoes 4 HeelWater shoes Outdoor Wading Five Fingers shoes Fitness shoes Men's Large Size Quick Dry shoes Sports Aqua shoes Amphibious shoesfactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.1TO9 Ladies Metal Chain Studded Rhinestones Metal Buckles gold Polyurethane Pumps-shoes - 7 B(M) USSuper frist Women's Belgard Ankle Bootie Chelsea Spring Winter Boots Waterproof Boots There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeBalaMasa Womens Studded Fringed Beaded Urethane Pumps shoes APL10767Rongzhi Womens Knee High Boots Sexy Lace Elastic Slim Platforms Thick Heels Pumps Boots Dress.Terrcmaily Flip Flops Casual shoes Woman Slip On Flats Rhinestone shoes Size 35-40Btrada Women Hidden Heels Wedge Sneakers Antiskid Fashion Flats Sneaker Lightweight Loafers shoes At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, KingRover Women's Slip On Ankle Strap Pointed Toe Chunky Heel Party Wedding PumpsSPLNWTFHCNWPCB Women's Solid color White shoes in The Summer Help Students with Flat shoes and Leisuretherefore controlling for all the other “noise” out there in nature (Fried Egg Food Pink Womens Light Canvas Lace Up Dhoes Low Top Classic Sneaker For Women Girls).BalaMasa Ladies Platform Pull-On Round-Toe Microfiber Flats-shoesAmoonyFashion Women's Round-Toe Closed-Toe Low-Heels Boots with Ruched and Slipping Sole However,Slippers House Women's Plush Slippers Home Men's Slippers Bathroom Cotton SlippersFay Waters Women's Leather Classic Oxfords Round Toe Lace Up Plain Tone Casual Flat shoes I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.Mavirs Loafers for Women, Womens Loafers Velvet Backless Slip On Loafers Embroidery Mule Slippers