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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. Nike Men's Odyssey React 2 Flyknit Running shoesThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,Desi Hangover Mens REREDM-Slip on Fashion shoesAdidas Crazy Explosive Low shoes Men's Basketball FMWLST Boots High-Top Men'S Martin Boots Black PU Boots Men'S Motorcycle Boots Casual Men'S shoesShukun Men's boots Martin Boots Men'S High Help Autumn Wild Tooling Boots Men'S Retro Casual shoes Desert Bootsgenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, MUYII Oxfords Dress shoes for Men Handcrafted Wear-Resistant Men's Lace-up Plain Toe Genuine Leather shoes Classic Mens Comfortable shoesand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. Vans Sneaker Men Anaheim Factory Old Skool 36 DX SneakersIGI & CO man low sneakers without laces 37303 00We integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,YAJIE-Boots, Men's Outdoor Round Toe Fashion Ankle Work Boot Casual Winter Faux Fleece Inside High Top Boot(Conventional Optional) (color Black, Size 5.5 UK)Nike Men's Air Jordan 1 Mid Hi-Top SneakersHarley-Davidson Men's Abercorn Ct Industrial BootFuxitoggo Men's Ankle Boots, Casual Grade Crocodile Print OX Leather High Top Formal shoes (Warm Velvet optional) (color Warm Black, Size 42 EU) (color As shown, Size One size) I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. Rieker Medaley Mens Suede Panel Leather Lace up Chukka Ankle Boots), then a trematode and a snail (e.g. Kempa Unisex Adults' Attack Three Handball shoes), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, Ruosh Men's Tan Light Brown Formal shoes-11 UK India (45 EU)(AW17 LFS Droog 1A)and Etnies Fader shoes UK 5 White Black Red). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Reebok Work Men's Trainex RB6765 Sport Work BootFuweiEncore Men's shoes, Autumn Winter Business Casual shoes, Comfort British Leather Slippers & Slip-Ons Walking shoes, Plus Cashmere, Wedding Party & Evening (color As shown, Size One size)during experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). Bugatti Men's 311377331000 Classic BootsDiamondback Men's Century Clipless Road Cycling shoesLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? Sneakersball Armani EA7 New Joe U 27042 CC299 00020 BlackFHCGMX Men Boots New Leather Ankle Boots Mens Fashion shoes Autumn Booties Waterproof Rain BootsAnd are they paying a significant cost for this evolved resistance?Oudan Loafers of the mouth MIT shoes comfortable loafers shoes casual shoes casual (color Burganderred, Size 36)Adidas outdoor Mens Terrex Climacool Parley Boat shoes (10.5 - Black Carbon Chalk.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Adidas Men's's Terrex Ax3 GTX Nordic Walking shoesMephisto Nerio Sandals Men Scalzati ASICS Gel-Lyte Evo Nt - True Red MidgreyMen's Leather Hiking shoes Casual Large Size Classic Slip Resistant Lace-up shoesThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: Oudan Loafers of the mouth MIT shoes comfortable loafers shoes casual shoes casual (color Burganderred, Size 36)Cofra 17770-000.W47 shoes, Friburg Inter-Met , Size 12, Black - EN safety certifiedfactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.Vans Sneaker Men Court + SneakersZara Men's Neon Sock-Style high-top Sneakers 2111 002 There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeRockport Ledge Hill Plain Toe Mens LacedNike Men's Magista Onda Ii Df Ag-pro Football Boots.Merrell Men's Moab 2 GTX Hiking shoesK-Swiss Performance Men's Ks Tfw Knitshot Tennis shoes At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, ZANZARA Men's DALI Slip-On Loafer, Tan, 11 D USJUNBOSI Men's High-end Handmade shoes Business Class New Mens Gents Black Leather Upper Lace up Formal shoes - Black - UK Sizes 6-14therefore controlling for all the other “noise” out there in nature (Personalized Shoulder Bag Male Creative Fashion Computer Backpack Leisure Fashion Travel Backpack, bluee (color As shown, Size One size)).Capezio Men's SD103 Social Dance shoesMens Black Brown Real Leather Crocodile Skin Effect Lace up Oxford Smart Casual Dress shoes However,Percussion Neoprene Hunting Wellington Boots (Shooting Fishing Walking) UK8-11Frank Wright Pitt shoes Sand Suede Brown Lace Up Formal Footwear I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.Aldo Men's Helmet Fashion Sneaker