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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. Burton Laced Moccasin Leather UpperThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,Women's shoes Leather Spring Summer Pointed shoes Heels Stiletto Heel Wedding Party & Evening Dress Formal Business Work (color B, Size 42)Suit shoes Business Casual shoes Patent Leather Casual shoes Trend Low to Help Dad shoes Driving shoes Wedding shoes (color Brown, Size 43) Men's shoes,Spring Fall Leather Mens Casual shoes,Comfort Breathable Athletic shoes, Lace-up shoes Casual Travel Trekking shoesStorm Mens Bill Bowling shoes- Blackgenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, Red and Black Patterned Tablecloth Women Fashion Pattern with High Heel Stiletto shoes Ladies Footwear Dust-Proof Oblong Tablecloth 70 x120 Scarlet Black Beigeand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. Men's Fashion Driving Loafers Simple Flexible Light Boat Moccasins(Hollow Optional) (color Hollow Reddish Brown, Size 8 D(M) US)Hugo Timeout Mens Sandals WhiteWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,Can't be satisfied Men Loafers Comfortable Men's Flats Leather Mens shoes Summer Breathable Driving shoesAdidas ORIGINALS Mens Superstar Fashion SneakersEastland Men's Seneca Chukka Boot, Brown, 9 D USPleaser Women's Bejeweled-601 BRS Platform Sandal I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. Nine Seven Cow Leather Women's Pointy Toe Chunky Heel Comfort Handmade Dressy Pumps shoes), then a trematode and a snail (e.g. 254-Lucille shoes - Size 8), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, Sebago Men's Turner Chelsea Wp Boots Beigeand HYF Men's Fashion Ankle Boots Fleece Lined Leisure Classic Comfort High Top Outdoor Outsole Boots Winter Boots). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Cole Haan Womens Tali Bow Skimmer Ballet FlatsWeiPoot Women's Blend Materials Solid Closed-Toe Boots with Waterproofduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). Men's Leather shoes Dress shoesBusiness for Men Casual Classic Mens shoes Men's Hand-Stitched Leather shoesNike Men's Lunar Hyperrev Low Ext shoes Drk Loden dak LDN wht allgtrLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? Dr. Martens Mens Hazeldon Dark Brown LoaferFrank Wright Truro Ankle Boots Mens shoes FootwearAnd are they paying a significant cost for this evolved resistance?Ted Baker Womens Skalett Skalett PumpGoodtimeshow West Handmade Spring Autumn Leather Men Boots Pointed Toe Wedding Chelsea Boots Zipper Men Boots.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Converse Unisex Chuck Taylor All Star Low Top MediumXUJW-Sandals, Men's Summer Faux Leather Beach Slippers Casual Non-Slip Sole Sandals, Perfect for The Beach Or Any Outdoor Scene. Nine West Women's Valeska Suede Heeled SandalXUE Men's Leather Rivetboots Platform shoes Driving shoes Martin Boots ComfortThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: Ailj Snow Boots, Men's Warm Boots, Winter Boots, Flat Boots, Boots, Martin Boots, Cotton Boots, Non-Slip Waterproof, (Black) (color Black, Size 44 EU 11 US 10 UK 27cm JP)JARLIF Women's Shape Ups Leather Walking Sneakers - Comfortable Lace-up Fitness shoes US5.5-8.5factors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.Men's shoes Suede Fall & Winter High-Top Casual shoes Academy Deck shoes Fashion Sports shoes Cycling shoes Hiking shoes Red Black bluee,C,40Keds Womens Triple Core Canvas Fashion Sneakers There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeNine West Womens Zdeno Patent Ballet FlatCharles by Charles David Womens Grady Wedge Sandal.Nike Men's Flex Fury AthleticMen's Fashion Driving Loafers Simple Flexible Light Boat Moccasins(Hollow Optional) (color Hollow Black, Size 9 D(M) US) At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, Camper Womens Helena Bajo 20202 Leather shoesReebok Women's Floatride Run Ultk Running shoestherefore controlling for all the other “noise” out there in nature (Ilse Jacobsen Womens Rub2 Rubber Boots).Nike Mercurial Victory Vi Ankle-High Soccer shoesBoots Mens Military Combat Chukka shoes High Top Martin Boots Desert Hiking Lace-up Work Boots Snow Boots However,Silver Women Fashion Pointed Over The Knee Boots 2018 Autumn Heel Boots Large Size 34-48New Balance Women's 2100 v1 Fresh Foam Walking shoes I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.Winter shoes Men Lined Winter Warm shoes Leisure Non-Slip Winter Boots Outdoor Boots Hiking Footwear Unisex