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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. Hush Puppies Mens Craig Luganda Formal shoes Black Size UK 10 EU 45The Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,Cole Haan Womens Zerogrand Stitchlite Oxford OxfordMen's Oxford shoes Soft Non-Slip Casual Driving shoes Leather Step n Style Men's Mehroon Sherwani shoes Pakistani shoes Padhani shoes Indian Nagra Khussa JuttiGLOBALWIN 1813 Mens Casual Slip-on Loafer shoes 8 Mgenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, Men's Athletic shoes, Suede,Spring Fall,Comfort Low-Top Sneakers,Lace Up shoes,Non-Slip Travel,Breathable Running shoes,Lightweight Walking shoes, Light Soles (color A, Size 41)and molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. Pantofola d'gold Imola Canvas Edition LowFLSHO Men's Classic Genuine Leather House Sandals Casual Slip On shoes Backless Loafers Office SlippersWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
Kenneth Cole New York Mens Eliott Lace Up Oxford
I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,Pleaser Womens Ado1017rsf C-mc Fsch BootHoxekle Winter High Heel Boots Leisure Elegant Heels Sexy Women shoes Warm Snow Boots Round Toe Thin Heel BootsGeox Women’s D Sukie A Low-TopDSFGHE Men's Martin Boots Classic Leather Chelsea Casual Non-Slip Combat Boots I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. Men's Boot, Large Size Martin Boots Autumn Casual Leather Ankle BootsTooling High-Top Plus Velvet Retro Boots Outdoor Hiking Boot Non-Slip Comfort XUE (color A, Size 42)), then a trematode and a snail (e.g. Men's Leisure Sneakers Booties, Fall Winter Plus Velvet Keep Warm Athletic shoes Men High-top Outdoor Loafers Running shoes (color 003, Size 40)), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, Nike Sb Portmore II Solar CNVS Mens Trainers 880268 Sneakers shoesand Nike Bravata IC Mens Indoor Competition Football Trainers 768924 Soccer shoes). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, STEVEN by Steve Madden Womens Nc-Slate Walking shoesBND-SHOES,Men's Fashion Ankle Boots Casual Light Comfortable and High-top Boots(Warm Velvet Optional) Durable,Stand Wear and Tear (color Warm Black, Size 10 D(M) US)during experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). Itasca Men's Neo Hunting Size Ankle BootWomen's Canvas shoes High-Heeled Platform Wedge Sneaker Peep Toe SandalsLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? GOMNEAR Men's Casual Running Walking Athletic shoes Breathable Quick Dry Lightweight Sneakers for BeachMen's Casual shoes, Genuine Leather shoes Autumn Fashion Sports shoes Fashion Youth Deck shoes Street Dance shoes Black Red YAN (color Red, Size 40)And are they paying a significant cost for this evolved resistance?Skechers Womens Burlap Wedge Espadrille Fashion SneakerWalking Cradles Womens Hemingway Boot.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).BONGZUO Business Oxford shoes, Men Dress Up Leather Personality British Style Trends Carved Brock Men Leather shoes Winter, YMP86-203Phil Betty Mens Hiking Boots Outdoor Non-Slip Lace Up Round-Toe Casual Martin Boots Diadora Unisex Adults' Game L Low Waxed TrainersSupra Skytop Iii Mens bluee Textile Lace Up Sneakers shoesThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: BRUNO ANTOLINI Oxfords-shoes Mens Leather BrownMen's shoes Casual Comfort Flat Loafers Spring Fall Comfort Loafers & Slip-Ons Lazy shoes Black White Brown,C,41factors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.Women's B.O.C, Averie Thong Sandal BROWN 9 MHYF Men's Ankle Boots Casual Classic High-top Plus Cotton Warm Non-slip Comfortable Work shoes Winter There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeSocofy Leather Ankle Bootie, Women's Vintage Handmade Buckle Pattern 7 B(M) USNike SB Mens Satire Mid 13 M US University Red Black White.Sam Edelman Womens Ava Ankle BootMen's shoes, Wear-Resistant Non-Slip Walking shoes Spring Fall New Outdoor Hiking Breathable Lightweight Camping shoes,A,44 At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, Spring and Autumn Men's Leather shoes Leather Patent Leather Business shoes Men's Casual Lazy shoes Round HeadDr. Brinkmann Herren-Pantolette blue 220240-5therefore controlling for all the other “noise” out there in nature (ARIAT Womens Fatbaby Original Work Boot).Rockport Men's Walk360 M SneakerClarks Women's Enfield River Ankle Boot However,Artola Brooklyn shoes Comany James Handsewn Penny LoaferLACROSSE Mens Burly Air Grip 12 Hunting shoes I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.Stacy Adams Men's Hewson Loafer