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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. Jordan Nike Grind 2 Mens Fashion-Sneakers AO9567The Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,Rockport Bayley Venetian Mens shoes blueeNike Internationalist Mid Red Black White 682844-606 Black Silver ASICS Men's Gel-Superion 2 Running shoesMen's Fashion Ankle Work Boot Casual Personality Splicing Winter Faux Fleece Inside High Top Bootgenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, HAWEEL Casual Sports shoes First Layer Cowhide + Microfiber Comfortable Solid color Casual shoes for Men (color Black Size 37)and molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. Enzo Romeo GNV2 Men's Wingtips Oxfords Perforated Lace up Dress shoes with Memory Foam Insole and Rubber Out Sole Black WhiteXAPPEAL Womens Carney Shin High Slouch Boot shoesWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,Le Coq Sportif Unisex Adults' Nationale Titanium Trainers GreyWinter Fashion Mens Boots Warm Comfy Booties Snow Stable Waterproof Flat shoes Large Size 38-43Santimon Men's Ankle Patent Leather Fashion Plaid Zipper Pointed Toe Casual BootsVans - Unisex Adult Classic Slip-On shoes I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. Nike Women's Air Zoom Structure 20 849577-501), then a trematode and a snail (e.g. Desai Mens Leather Lace Up Formal Evening Brogue Oxford shoes in Brown), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, Feifei Men's shoes Men's High Help Martin Boots Winter Snow Men's shoes Warm Cotton shoes (color 01, Size US7.5 EU38 UK5.5 CN38)and Naot Women's Alana Wedge Sandal). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Flair Sky Run FW Men's Sport shoes Trainers Running Outdoor Indoor FitnessFrye Womens Tina Whipstitch Tassel Bootduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). Skechers Mens Summits Athletic shoesCreative Recreation Carda Hi Athletic Men's shoes SizeLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? Vintage Foundry Men's The Coltan Cap Toe DressReebok Mens Crossfit Nano 7.0 SneakerAnd are they paying a significant cost for this evolved resistance?Lugz Mens Vet Denim SneakersBugatti - Kodiak - 3425186269007100.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Snowman Lee Outdoor Climbing Casual Frosted Leather Lace Up Men 's shoesMen's Casual Leather shoes, Large Size Business Mens shoes Newest British Footwear (color Brown, Size 39) DESAI Men's Dress shoes shoes Brogue Perforated Wing-Tip Oxford Genuine LeatherGLOBALWIN Women's YY03 Grey Fashion Snow Boots 8.5MThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: DANIELE ALESSANDRINI Maglia Giro Print SFILATA FM51169L3401Adidas Lux Men's Hockey shoes Red, orangefactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.Steve Madden Men's Helman-A Chukka BootMark Nason Los Angeles Men's Culver Fashion Sneaker There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeMen's Boots Motorcycle Boots Autumn and Winter Men's High-Top Casual Boots Men's Cotton shoes Martin Boots Non-Slip Waterproof Racing Boots Leather BootsES Men Accel Slim Navy Tan White shoes Size.Ted Baker Womens Kawaa PumpKEEN Men's Dillon II Slip On shoes At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, Official Kappa Farul Trainers Mens Athleisure Footwear shoes SneakersDrMartens Besra SD Mens 15789240therefore controlling for all the other “noise” out there in nature (AnMengXinLing Fashion Ankle Chelsea Boots Women Low Stacked Block Heel Real Leather Pointed Toe Elastic Slip On Business Work Boots).Men's Leather Martin Boots Plus Velvet Bull Carved Chelsea Men's Leather BootsDesi Hangover Genuine Premium Leather Handmade Mens Casual shoes Slip-on Loafers Hola Brown shoes, Free Express Shipping However,Vlado Footwear Men's Hits Leather Low Top Wingtip SneakersBearpaw Women's Lea Fashion Boot I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.HAPPYSHOP TM Men's Patent Leather Fashion Moccasins Comfort Driving shoes for Any Occasion