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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. Pantofola d'gold Mondovi men MidThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,Adidas Alphabounce RC shoes Women's RunningHAPPYSHOP(TM Mens Simple Retrospect Leather Moccasin Comfort Slip-on Driving shoes Loafers Black WeiPoot Women's Elastic Fabric Solid Closed-toe Boots with Winkle Pinker and Non-Slipping SoleFreebird by Steven Women's Emory Ankle Bootsgenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, Andrew Marc Men's Dyker Oxfordand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. Dig dog bone Men's Business Oxford Casual New Crocodile British Style Round Toe Formal shoes.ILHABELA HOLDINGS INC Melissa Womens Harmonic XIII Flip Flop SandalWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,shoes Men Oxford shoes Mens Formal shoes Slip On Style OX Leather Comfortable Low-top Breathable Outsole Simple Solid color (color Light Brown, Size 11.5 D(M) US)Fila Men's Decimus 3 Training shoesSteve Madden Mens Tazman LoaferSam Edelman Womens Kassie Sneaker I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. Men's Fashion Driving Loafer Casual Solid color Comfortable Convenient Carving Brogue Big Size Boat Moccasins (color Red Brown, Size 10.5 D(M) US)), then a trematode and a snail (e.g. Nike Women's Viale Running shoes), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, Men's Fashion Driving Loafers Casual Personality Simple Retro Lightweight Boat Moccasins (color Brown, Size 9 D(M) US)and Converse Hi Top White Silver). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Jack Wolfskin Mens Lakewood Cruise Sandal Men's Travel Sandal Sport SandalPropet Pedwalker 15 Medicare HCPCS Code = A5500 Diabetic shoesduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). Plum Fog Pro Purple Nike 5 Inch Race Day Running ShortsAmblers Safety Mens FS39 Waterproof Lace up Safety Boot Brown Size UK 9 EU 43Local biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? 206 Collective Women's Everett High Heel Ankle BootieAilj Snow Boots, Men's Warm Boots Leather Plus Velvet Winter Boots Martin Boots Short Boots Cotton shoes Non-Slip (2 colors) (color Brown, Size 41 EU 8 US 7 UK 25.5cm JP)And are they paying a significant cost for this evolved resistance?Tony Lama Men's Scalloped Leather Belt - 9119LLondon Brogues Hutton Mens Single Strap Monk shoes.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Kenneth Cole New York Mens Big Plus Slip On Loafer Dress shoesLIJUN Snow Boots Winter Men Non-Slip Warm Martin Snow Boots Genuine Leather Winter shoes Outdoor Travel Size：38-46 Oxford shoes for Men Formal shoes Slip On OX Leather Low Top Round Toe shoes (color Black Hollow, Size 8 D(M) US)Converse Women's Point Star Low Top Sneaker WhiteThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: Bill Blass Women's Carmen 65AnMengXinLing Rivet Studded Ankle Boot Women Block Low Heel Pointed Toe Leather Buckle Strappy Punk Cowboy Chelsea Bootfactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.SKECHERS shoes men low sneakers 52518 BEIGEHappy Feet Mens and Womens Boston Bruins Sneaker Slippers Black There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeSaucony Men's Zealot ISO Road Running shoesConverse Chuck Taylorr All Starr X Nike Flyknit Hi Black Wolf Grey White shoes.Rockport Women's Truwalk Zero Moreza Mesh Mary Jane FlatJsix Men's Real Leather shoes Slip On Buckle Strap Crocodile Embossed At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, Payntr Rubber Cricket shoes by Seven WhiteT-mod Comfortable Non Slip First Layer Genuine Leather Boots Stylish Casual Work shoes for Mens Browntherefore controlling for all the other “noise” out there in nature (Portwest UFW17HOR0070 Regular Fit Steelite Welted Safety Boot, Size 70, Honey).Men's Leather shoes Daily Casual Top Layer Cowhide Leather shoes Non-Slip shoes shoes Adhesive shoes Breathable Non-Slip WearReebok Womens Crossfit Nano 4.0 Cross Trainer However,361 Men's Spire Running shoesCALTO Men's Invisible Height Increasing Elevator shoes - Black Premium Leather Lightweight Lace-up Formal Oxfords - Y41312-3 Inches Taller I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.Deltaplus Men's D-Spirit S1P Low shoes US Size 13 Black