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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. shoes19 Women's Mid Calf Combat Boots, 9 B(M) US, Black PuThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,Converse Hi Top White SilverMen's Breathable Driving Loafer Flat Heel Crocodile Skin Texure Wave Sole Moccasins shoes Business Casual shoes Men's shoes Lazy Leather shoes First Layer Cowhide Leather shoes Round Head shoesDriving Loafer for Men Business Boat Moccasins Slip On OX Leather Comfortable Low Top shoes (color Black, Size 10 D(M) US)generating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, Vasque Women's Talus Trek Low UltraDry Hiking shoesand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. MNX15 Men's Elevator shoes Height Increase 2.7 Envy blueeFrank Wright Truro Ankle Boots Mens shoes FootwearWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,London Brogues Chad Mens Lace Up Brogue shoesAutumn and Winter Men's shoes Trend First Layer Leather High-top Sneakers Wild Men's High-Country Running shoesSKDOIUL Men's Fashion Mesh Trail Sport Running shoes Breathable Lightweight Casual shoes for Boys Red Size 8 (1818-red-41)FSJ Women Fashion Ankle Booties High Platform Thick Heels Black Glossy Patent shoes Floral Size 4-15 I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. Skechers Men's Track - Bucolo, Athletic, Red Black,), then a trematode and a snail (e.g. Josef Seibel Klaus - black Kombi (Black) Mens shoes), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, Men's outdoor boots in the autumn hiking shoesand NANOTECH Casual LACE UP CONFY shoes Antonio Black). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Ailj Snow Boots, Men's Leather Padded Plush Warm Boots Flat Waterproof Short Boots Non-Slip Cotton shoes (2 colors) (color Black, Size 39 EU 7 US 6 UK 24.5cm JP)Chung -Shi Duxfree Aruba Women Cross Trainersduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). 206 Collective Women's Everett High Heel Ankle BootieBONGZUO Chelsea High Oxford Boots, Men Real Leather Boots Warm European and American England Three Joints Formal Business Boots, YMX86-SX2Local biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? Diesel Men's Happy Hours S-Aarrow Fashion Sneaker5.11-12018 Men's A.T.A.C. 6 Side-Zip BootAnd are they paying a significant cost for this evolved resistance?Nike AIR MAX 90 Ultra SE - 845039-006Nike Mens Air Humara '17 Premium Steel Grey Volt Synthetic.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Nike AIR OSCILLATE Mens Fashion-Sneakers 140370Men's Dress shoes Men's shoes Peas shoes Leather Driving Casual shoes High-end Handmade shoes Zhougang Summer Slingbacks Women shoes Pumps 7.5 cm Pearl High Heels Pointed Toe Sexy shoes with HeelsMen's Casual shoes Sneakers Flat shoes Slim Business shoes Men's shoes Comfortable (color Black, Size 39)The costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: Charcoal bluee Skechers Work Sure Track Flinser Alloy Toe Womens Sneakers3 color US Size 5-12 New Genuine Leather Formal Dress Loafers Mens shoes Beigefactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.Nike Men's Air Max Tavas White White Black Running shoes 7 Men USDemonia Womens BEAR-120 GYVL Boots There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placePortwest UFW17HOR0070 Regular Fit Steelite Welted Safety Boot, Size 70, HoneyJosef Seibel Mens Boos Mgold, Leder, 670459-2.WoolWorks Model 9778 Mens Australian Sheepskin Slippers - Soft Leather SoleNew Balance Womens 890v6 Running shoes At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, Men's Leisure Driving Loafers Round Toe Oxfords Casual Flat Penny shoes Leather Upper Slip On Walking Lightweight Boat shoes (color Black, Size 9 D(M) US)Fulinken Men's Fashion Velvet Slip-on shoes Round Toe Mens Casual Embroidered Loafers (9.5, Dark bluee)therefore controlling for all the other “noise” out there in nature (KEEN Men's K-30 Medium Outdoor Insole, bluee S Regular US).GFP Men's Leather shoes Formal Business shoes Men's Fashion shoes Pointed shoes Walking shoes Wedding Party & Evening Leather shoesToto - H32161-2.2 Inches Taller - Size 10 D US - Height Increasing Elevator shoes (Black Leather Slip-on Moc-toe Super Lightweight Casual shoes) However,Nike Runallday Mens Running Trainers 898464 Sneakers shoesOriginal S.W.A.T. Men's Metro 9 Tactical SZ Air Work Boot I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.Fred Perry Vintage Tennis Canvas Red