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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. INMONARCH Mens Ivory Polyester Wedding shoes Floral Pattern MJ010159The Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,INMONARCH Mens White Wedding shoes Checks Prined MJ017012Sam Carle Men's Dress Oxfords Spring Black Brown Business Daily Casual shoes Naturalizer Womens Morrison 3 SneakerRajwada Men's Padhani shoes Lahori Royal bluee Velvet Nagra Juttigenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, Kenneth Cole New York Womens Vida Slip on Sneaker Sneakerand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. Lucky Brand Womens Prucella Ankle BootIzod Mens Cally Chukka BootWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,Xinnio Men Indoor Fashion Retro Striped Linen Summer Slippers SlidesMen's Sports shoes, Fashion Leather Deck shoes Low-top Sneakers Outdoor Lace Up Hiking shoes Fitness & Cross Training shoes YAN (color C, Size 39)HAPPYSHOP(TM Men's Crocodile Leather Casual Slip-on Loafer Flats Moccasin Driving shoesVEPOSE Men's Dress shoes Formal Square Toe Lace up Oxfords I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. HUAN shoes Mens Casual shoes Lightweight Lace-up shoes Comfort Sneakers Running shoes), then a trematode and a snail (e.g. ASICS Mens Mens Gel-Rocket 8 Volleyball shoes), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, K-Swiss Mens St-329 Fashion Sneakerand Cambridge Select Women's Retro 90s Ugly Dad Lace-Up Chunky Platform Fashion Sneaker). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Driving Loafer for Men Boat Moccasins Slip On Cowhide Leather Lightweight (color Dark Brown Hollow, Size 10.5 D(M) US)Lauren by Ralph Lauren Womens Latasha Pumpduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). Rieker Men Schnuerer, Freizeitschuhe Pazifik Denim, Leder, 641061-5Bugatti Men Lace-Up shoes brown, (dark brown) 311374011100-6100Local biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? Steve Madden Mens Averie OxfordGAOLIM Solid color Round Head Light-Slotted Strap With Single Women In shoes With Bold shoes Student shoes Trend.And are they paying a significant cost for this evolved resistance?Mens Sandals Open Toe Flat Beach shoes Summer Outdoor Sandals Slipper shoes Hiking Trekking Walking Sandals Size 5-9(39-46),a,43Florsheim Mens Franklin Penny Penny Loafer.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Gnarly Tees Men's Dentist Pattern SneakersGnarly Tees Men's Skydiving shoes High Top Duckmole Men's Fashion Classic Leather Driver Loafers Leisure Soft Comfortable Flexible Slip-on shoesBemy Leisure Sports Men's shoes Outdoor Sports shoesThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: Nike Mercurial Victory Turf Soccer shoes (VOLTAGE CHERRY DARK OBSIDIAN)Dickies Men's DK6222 Work Bootsfactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.Gnarly Tees Men's Photography Camera shoes High TopSpring and Autumn Tide Men's Fashion Casual Hiking shoes Men's Outdoor Sports shoes Hiking wear-Resistant Non-Slip shoes,42 There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeEurbak Men's Extra Wide Width Winter Black Boots Style 3754Misu Women's Peep Toe Sandals Latin Salsa Tango Practice Ballroom Dance shoes with 3.0 Heel,Silver Satin and Glitter,13.0 B(M) US.HUAN Mens Casual shoes Flat Loafers Deck shoes British Style Trainers shoes Fashion Running shoes SpringHiking shoes Men Tactics Military Sneakers Trekking Non-Slip Boots At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, Men's Casual shoes,Spring Summer Fall Loafers & Slip-Ons Walking shoes Light Soles Comfort Driving shoes,a,41Tredters Women's Harlowe Ballet Flattherefore controlling for all the other “noise” out there in nature (DSFGHE Leather shoes Men Wedding Formal Leather Black Booties Adults' Vintage Business Chelsea Boots Office Work Non-Slip Brown Ankle Boot Fit Men's).Betsey Johnson Womens Traci Wedge SandalWLJSLLZYQ Breathable shoes Men's Summer feet Mesh shoes One Lazy mesh Sports shoes However,Reebok Mens Club C 85 Estl SneakerSkechers Men& 39;s Relven-Velton Sneaker I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.U-lite Mens Cap Toe Brown Business DressOxford, Open Lace-up Vintiage Bred shoes