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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. Nike Hypervenom Phelon FG - Hyper bluee Volt BlacThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,Beaumens Women's Lace-up Platform High Heels Fake Leather Short BootsLaforst Gerry 9400 Mens Work Slip Resistant Composite Toe Oxfords HUAN Mens Leather shoes Wedding Pointed Toe Formal Business Work Comfort Casual Dress shoesSpring Step Womens Coed Slip-On Loafergenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, Mens Beach Sandals Real Leather Sandals, Sports Outdoor Walking shoes Closed Toe Slip on shoes Breathable Hiking Anti Collision Slippersand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. HAPPYSHOP(TM Men's Winter Casual Suede Budge Leather shoes Comfort Slip-on Tassel Loafer Driving shoes BrownPhil Betty Mens Martin Boots Autumn Winter Outdoor Casual Non-Slip Cotton BootsWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,Men Boots Autumn Adult Martin Boots Leather Tooling Chelsea Boots High to Help Desert Snow Boots Non-Slip Breathable Fighting shoesColumbia Mens BugabootTM Ii XTM Snow BootMerrell Mens Jungle Ayers Lace MoccasinMen's Slip-On & Loafers，Spring Fall Microfiber Work shoes ，Single shoes Driving shoes Shallow Mouth shoes，Occupation, Offic (color B, Size 43) I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. Hey Dude Slip On Men shoes Farty Brown Nut Suede Mule Leather Lined Insole), then a trematode and a snail (e.g. WLJSLLZYQ Men's Casual shoes Flat shoes Suede Summer Sports shoes), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, Pierre Dumas Women's Hester-6 Wedge Sandaland Alibress Men's Women's Lightweight Breathable Athletic Sneakers Mesh for Walking Running Sport Gym shoes). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Mens Basketball shoes High-Top Outdoor Sneakers Running Trainers Jogging Athletic shoesGiles Jones Mens Outdoor Waterproof Casual Breathable Durable Anti-Slid Hiking shoesduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). Adidas Performance Mens Crazytrain Boost Cross Training Trainers - BlackMens Outdoor High-Top Safety Boots Sports Non-slip Boots Lace-up Hiking shoes (Sand color, 40)Local biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? Seychelles Womens Remembrance Ankle BootTD S83147 Sandals Men Breathable Beach Sandals (color Khaki, Size EU44 UK10 CN46)And are they paying a significant cost for this evolved resistance?Men's Sneakers, Spring Fall Fashion Leather Lace-up shoes, Comfort Outdoor Casual Sneakers,Fitness shoes Breathable Running shoesColumbia Men's Drainmaker 3D Boat.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Amblers Safety Mens AS335 Pgoldn XRD Internal Metatarsal Safety Boot Black Size UK 5 EU 38Naughty Monkey Womens Slip Knot Oxford HAZPROOF 82330.08 11 Sure Grip Steel Toe Midsole Boot, Size 08, orange CreamMas Artisan Womens Ulla Ankle BootieThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: H By Hudson Mens Tasker Calf OxfordTeva Men's TERRA FI LITE Sandalsfactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.Mens Running shoes,Black Walking shoes,red Sports shoes,White Trainers Men,Webbing+mesh,net LiningEastland Mens Sebring Boat shoes There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeCobb Hill Rockport Women's Jennifer Wedge PumpSnowman Lee Men's Penny Loafer Leather shoes Zipper Driving Walking Slip-on shoes.Franco Sarto Womens Connolly Wedge SandalDaya by Zendaya Women's Aaron Pump At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, Supra.. Men's Hammer Run Lightweight Trainer Runner shoesAmerican Rag Womens Ada Closed Toe Knee High Fashion Bootstherefore controlling for all the other “noise” out there in nature (Converse Mens Chuck Taylor All Stars Tropical Print Hi Top Canvas Trainers).Converse Women's Chuck Taylor All Star Madison Low Top Sneaker,ASICS Men's Met Conviction Training shoes However,Dansko Womens Luann Ankle BootA X Armani Exchange Men's Retro Running Fashion Sneaker I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.Sport Sandals Men's Sandals Summer Outdoor Beach shoes Soft Open Toe Sandals Casual Youth Sports Slippers Retro Breathable Roman shoes (color Brown-B, Size 5.5UK 7.5US)