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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. Donald J Pliner Womens Rue MuleThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,Men's Casual shoes Microfiber High-Top Deck shoes Lace Up Hiking shoes Fitness & Cross Training shoes Walking shoes Black White Red,Red,44Nike Stefan Janoski Max Mens 631303-304 MUMUWU Men Business Oxford Leisure Personality Embodying British Style Formal shoes Semi (color Black Tie, Size 6 D(M) US)Mens Gents Black Slip On Wider Fitting Casual shoes Leather-Lined Lightweight Formal Business Work Comfort Lace-Up, Slip-on or Touch Fastening shoesgenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, Helly Hansen Men's Trysail Boat shoesand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. Lacoste Men's Chaymon BL 1 CMA Leather Trainers, BlackMen's Snow Boots Winter High Top Martin Outdoor Boots Warm Suede Waterproof Lace Fur Lined Work shoes Non Slip Size：38-47We integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,Kamik Mens Greenbay4w Snow BootSATUKI Adult Men's Antiskid Waterproof Rubber Sole Work shoes Rain Boots BlackHush Puppies Mens Runner Slip On shoes Navy Size UK 8 EU 42Men's Boots Vintage Country Boots Outdoor Riding Knight Boots Simple Zipper Cowboy Boots for Autumn and Winter I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. Men’s Sneakers, Hiking shoes,Men's New Breathable Running shoes, Mesh Casual shoes,Men Korean Version Tide Wild Sports shoes, (color B, Size 39)), then a trematode and a snail (e.g. Adidas Men's Ace 16.3 Primemesh Turf Soccer shoes Green), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, Adidas Men's Nemeziz Messi Tango 17.3 Tf Soccer shoesand PUMA Men's Powercat 1 FG Soccer Cleat). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Tundra Men's Abe Winter BootMerrell Womens City Leaf Tall Snow Bootduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). Eastland Men's Chester Hiking BootsStacy Adams Men's Sanfillipo Oxford TanLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? Propet Women's Piccolo Hiking Boot, Grey Mint, 6H 2E USChampion 3 On 3 MensAnd are they paying a significant cost for this evolved resistance?Men's Business shoes ，Men's Uniform Dress shoes，Leather Lace-ups shoes，Spring Fall Pointed Toe shoes， (color C, Size 44)Clarks Women's, Leisa Lakelyn Sandals White 6 W.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Diesel Womens SKB S-kby SneakerTherafit Women's Flora bluee sandals 9 W El Naturalista N5010 Women's Sabal SandalsDC Mens Muirland Lx Fashion BootThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: Vans Mens Av Native American Low Sneakers Navyblack 6.5Easy Strider Men's Original Iconic Casual Boat shoes - Perfect Comfortable for Every Day Fashion Classic Style -Making You Easier to Walk with Comfortable Microsuede Liningfactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.Santimon Dress shoes for Men Alligator Crocodile Print Leather Derby Derby Lace Up Casual Oxford shoes shoesPolo Ralph Lauren Mens Train100mid Sneaker There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeSantimon Mens Dress Fur Leather Oxford Round Toe Lace Up Derby Ankle Winter Boots BlackWomen's Bare Traps, Gardyna Tall Shaft Boots.ZOCAVIA Womens Slip On Sneaker Mesh Loafer Casual Beach Street Sports Walking shoes, Purple, 10 B(M) USFly London Womens Port813fly Sandal At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, ECCO Footwear Womens Touch Ballerina 2.0 Scale Ballet Flat, Black Black, 35 EU 4-4.5 M USCasssa Leeni Men's Running shoes Casual Athletic Sneakers Mesh Sports shoes Tennis shoes for Men Breathable Lightweighttherefore controlling for all the other “noise” out there in nature (Hummel Women's Victory Trainers, Purple, 7 UK).WeiPoot Women's Pu Closed-Toe Solid Low-Top High-Heels Boots, EGHXI112211DC shoes Mens NET SE Nubuck Black Herringbone Trainers 10.5 US However,PUMA States X Vashtie Estate bluee SizeClarks Womens Aubria Fay Flat I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.Rialto Womens 'CHARLEE Closed Toe Classic Pumps