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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. Men Leather shoes Casual Oxfords Business Dress shoes Formal Pointed Fashion Wedding shoes Black Brown,Brown,39The Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,Adidas Mens Twinstrike ADV Stretch Lea Black White LeatherHAWEEL Casual Sports shoes Round Head Solid color Comfortable and Wearable Casual shoes for Men (color Black Size 37) MUMUWU Men's Genuine Leather Casual Slip on Moccasin Loafers Breathable Driving shoes Fashion Slipper (color Brown, Size 7 D(M) US)Lonsdale Trinity Trainers Mens shoes Sneakers Footweargenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, TG8052039 SAFETY shoes Jumper S3 ESD Src Size 39 In Black-Limeand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. Metrocharm MC602 Men's Lace Up Cap Toe Perforated Classic Dress shoesHiking Outdoor shoes Leather Anti-Skid Shock Absorption Breathable Camping shoesWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,KINGSHOW 1428 Water Proof Men Rubber Sole Winter Snow Boots Brown size 10.5MUMUWU Men's Ankle Boots Casual Personality OX Leather Large Size Suede High Top Work shoes WinterBugatti Men's Men's Licio Leather Lace-Up BroguesMen's Casual Sports shoes Fashion Sneaker for Men Lace Up OX Leather Pleated Texture Sports shoes Lightweight Walking Sneakers (color White, Size 7 D(M) US) I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. W&P Men's basketball boots cushioning wear-resistant anti-slip shoes), then a trematode and a snail (e.g. Cat by Caterpillar Men's Weldon Boots Black 11.5 M), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, LifeStride Women's Absolutely Not Dress Pumpand LIJUN Men's Snow Boots Waterproof Non Slip Booties Warm Comfy Hi-Top Work shoes). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, MUMUWU Men's Fashion Ankle Work Boot Casual Vintage Brushed Outsole Lace Up Winter Faux Fleece Leather (color Brown, Size 11 D(M) US)COSDN Men's Fashion Air Cushion Shock Absorption Comfortable Basketball shoes Sports Running Tennis Casual Sneakers(US 6.5～11)during experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). K-Swiss Mens Classic Vn Camo Sp SneakerMen Martin Boots Leather top Layer Leather Tooling shoes lace up Fleece Lined Non-Slip Casual shoes Autumn and Winter NewLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? ABSOLUTE FOOTWEAR Mens Slip On Slippers Boots Indoor shoes with Warm Faux Fur InnersNimbishoes Mens Popular PU Leather Suede Round Toe Lace up Classical Casual Oxford Dress shoesAnd are they paying a significant cost for this evolved resistance?Santimon Men's Leather Brogue Fashion Wingtip Lace-ups shoesBostonian Men's Maynor Free Slip-On Loafer.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Giles Jones Men's Hiking Boots Tactical Breathable Camping Climbing Mountain BootsVia Spiga Women's V-BAYLIE2 Ballet Flat Attain Sunshine Ltd Men's Leather Slippers Non Slip Sturdy Sole House shoes Fur Memory Foam Warm Indoor & OutdoorASICS Men's Gunlap Track and Field shoesThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: Converse X Woolrich Chuck Taylor All Star HIGH TOP Mens Fashion-Sneakers 153835CXIANGBAO-Personality Oxford for Men Low Stacked Heel Lace up Actual Leather Business Conventional Wedding shoesfactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.Adidas Adizero Club Tennis shoes - SS19Pleaser 5 Heel Ankle Boot W Metal Stud Detail, Side Zip Mens Boots There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeTeva Hurricane XLT2 Sandals - SS19Columbia PFG Men's Bahama Relaxed Marlin PFG Boat shoes.Converse Unisex Adults' CTAS Ox Jute Vintage Khaki Ash Grey TrainersHAWEEL Casual Sports shoes Simple and Fashionable Wild Casual shoes for Men At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, Men's Leather shoes 2018 New Business Formal shoes Dress shoes Wedding Prom Party & Evening Leather shoes,B,42MUMUWU Oxford shoes for MenLace Up Style OX Leather Classic Pure color Round Toe Formal shoes (color Brown, Size 7 M US)therefore controlling for all the other “noise” out there in nature (Autumn Men's First Layer Leather Low Cut shoes England Outdoor Large Size Men's shoes Thick-Soled Wear Casual Big shoes).Penguin Birdie Mens Leather Moccasin shoes - Black - SIZE US 11Men's Boots, Leather Fall Winter Chelsea Boots Anti-Fur Boots Wild Casual Boots Trend High-Top Desert Boot Pointed Retro Male Martin Boots XUE (color B, Size 41) However,Heaton Egyptian Sandals Men's shoes Size 13Men's New Boots Fall Winter Tooling Booties Casual Comfortable Leather shoes Flat Lace-up Driving Ankle Boots (color A, Size 42) I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.New Balance 624V4, Men's Running shoes