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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. KENDALL + KYLIE Womens Haven2 Fashion Pointed Ankle BootsThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,Longxing Suede Gommino Causal Women Thin shoesBIGTREE Womens Knee High Boots Chunky Heel Fur Lined Riding Boots Belt Buckle with Side Zipper Winter Motocycle Boots 2019 Summer Women Pumps Sexy Sequined Pointed High Heel shoes Ladies Stiletto Party Wedding shoesUirend Women Knee High Sandals for Summer Flat - Ladies Fancy Dress shoes Zipper Gladiator Sandals Peep Toe Slingback Fashion Charms Wide Fit Casual Bootsgenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, INC International Concepts Womens Guyen Open Toe Special Occasion Slide Sandalsand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. HCHBE& Cute Cat Warm Boots Women Family Christmas Cotton Winter shoes Women Boot RedCdon Mule Slides, Womens Backless Slip On Loafers Tassels Pointed Toe Slipper shoesWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,Artfaerie Women's Block Heels Ruched Mid Calf Slouch Boots Slip on Autumn Winter shoesArtfaerie Women's Stiletto High Heels T-Strappy Sandals Open Toe Platform Pumps with Pearls Ladies Dress shoesShowudesigns Cool 3D Animal Design Soft Women's Lightweight High Top Canvas shoesSoludos Women's Embroidered Smoking Slipper Flat White I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. CHENGXIAOXUAN Women's New Sandals Wedge-Heeled Flip-Flops Summer Non-Slip Sandals Flowers Beach shoes Fresh Women's Flippers Girlish Sandals with Height 5.5cm), then a trematode and a snail (e.g. AIYOUMEI Women's Ankle Strap Block Heel Platform Pumps shoes), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, AIYOUMEI Women's Peep Toe shoes Glitter Platform Stiletto High Heels Sandals with Bowsand Alfani Womens Fleurr Open Toe Casual Slide Sandals, Quartz, Size 6.0). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Excellent.c Latin Dance shoes Girls Ladies Dance shoes Buckle SandalsNopersonality Womens Running Tennis shoes Lightweight Casual Walking Sneakersduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). Rongzhi Womens High Heels Block Heels Pumps Cross Ankle Strap Heeled Sandals Dress Party shoes Open ToeForever Link Women's Slip On Smoking Loafer Slipper FlatLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? Fashion shoesbox Womens Winter Suede Warm Ankle Boots Ladies Casual Low Heel Round Toe Flat Paltform Ankle BootiesFashion shoesbox Women's Fashion Calf Flat Boots Side Buckle Outdoor Slouch Waterproof Faux Fur Warm Short BootiesAnd are they paying a significant cost for this evolved resistance?KemeKiss Women Fashion Hidden Heel Platform Boots Winter Warm Pull On BootiesFANIMILA Women Fashion Lace Up Flatform shoes Multicolor.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).AvaCostume Womens Hibiscus Embroidery Frog Design Wedge Heel SneakerTAOFFEN Women Winter Outdoor Zipper Snow Boots Warm Inner Hlaf Boots Spring Step Womens Yared Ballet FlatAGOWOO Women Sandals Cool Skull Beaded Ankle Strap Gladiator Thong BeachThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: Unyielding1 Women's Ballroom Dance shoes Latin Salsa Dance shoes T-Strap Sandals Latin shoesKyle Walsh Pa Women Casual Square Toe Bow Slip-On Flatsfactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.Angelliu Women Sweet Bowknot Leather Foldable Ballet shoes Loafer Flats RedMe Too Women's Nicki 14 Ballet Flat There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeCloth shoes, Ribbed Sole Embroidered shoes, Dancing shoes, Women's shoes-YU&XinH-M-STUDIO New Autumn and Winter Retro Solid color Wide Shoulder Messenger Bag Brown 17 13 7Cm.Water shoes Mens Womens Outdoor Swim Barefoot shoes Quick Dry shoes for Beach Running Snorkeling Surfing Diving Yoga ExerciseKaloosh Women's Denim Sexy Pointed Toe Thin Heel Court shoes Dark bluee At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, Cotton and Linen shoes Comfortable College Wind The Wind Canvas shoes-YU&XinLa Auténtica 807FB - Desert Boot Lined, Unisex Adult, Navy blueetherefore controlling for all the other “noise” out there in nature (New face Womens Sandals shoes Woman Genuine Leather Flat shoes Fashion Hand-Sewn Leather Loafers Female Hole Hole shoes Women Flat).Bjakin Air Mesh Woman Aqua shoes Summer New Water Beach shoes Water shoesDecoStain Women's Classic Pointed Toe Patent Leather Slingbacks Slip-on Mid Thin Heels Daily Working Pumps shoes However,KingRover Women's Platform High Heel Ankle Strap Peep Toe Dress Sandals with BowStep n Style Traditional Indian Women shoes Leather Jutti Handmade Mojari Flip-Flops I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.Indoor Home Slippers Warm Soft Plush Slippers Comfortable Pure Indoor Slippers Cute Women shoes